Gating Cycle of the Human Multidrug Transporter P-Glycoprotein (PGP) Schematic

  • PGP_schematic_Falconieri

Human Multidrug Transporter P-Glycoprotein (PGP) is a membrane protein capable of exporting a variety of molecules out of cells. In some cancers, it contributes to drug resistance by removing drug molecules from the tumor cells.

This schematic graphic summarizes the findings of a cryo-electron microscopy (cryo-EM) paper featuring 10 different structures of the human multidrug transporter P-glycoprotein (PGP), and places them in context of PGP’s ATPase cycle.

Published in Frank, G. A. et al. Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle. Mol. Pharmacol. 90, 35–41 (2016).

Veronica Falconieri/Subramaniam Lab/CCR/NCI/NIH