Small Molecule Induced Polymerization and Degradation of BCL6

  • BCL6 filament

Targeted protein degradation is a powerful potential therapeutic approach. Here, cancer-related protein BCL6 is bound by a novel small molecule inhibitor (blue) that causes filament formation and subsequent degradation.

Cover art submission based on: Słabicki M, Yoon H, Koeppel J, et al. Small-molecule-induced polymerization triggers degradation of BCL6. Nature. 2020;588(7836):164-168. doi:10.1038/s41586-020-2925-1

Structures: PDB 6XMX